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Initiating Azathioprine for Crohn's Disease 
Azathioprine (AZA) and 6-mercaptopurine are therapeutic options for patients with moderate to severe inflammatory Crohn's disease. AZA has both a complex metabolism and potential for adverse events that can be clinically challenging. AZA has been shown to maintain remission and reduce corticosteroid use in patients with Crohn's disease.
Issue Highlights
Endoscopy Corner
- Identification of Cholangiocarcinoma by Using the Spyglass Spyscope System for Peroral Cholangioscopy and Biopsy Collection
The Spyglass Spyscope for cholangioscopy and biopsy collection identified malignancies with 77% accuracy in patients with suspected cholangiocarcinoma.
Original Articles—Alimentary Tract
Antimicrobial Antibodies Are Associated With a Crohn's Disease–Like Phenotype After Ileal Pouch–Anal AnastomosisAntimicrobial antibodies and pANCA are associated with inflammatory complications of the pouch. The CDL phenotype is associated with factors that characterize Crohn's disease, including smoking, anti-CBir1, and ASCA.
Original Articles—Liver, Pancreas, and Biliary Tract
- Telbivudine Prevents Vertical Transmission From HBeAg-Positive Women With Chronic Hepatitis B
Women with CHB given telbivudine during the second or third trimester of pregnancy have reduced rates of perinatal transmission. Telbivudine produced no adverse events in mothers or infants by 28 weeks.
Safety of Cardiac Surgery for Patients With Cirrhosis and Child–Pugh Scores Less Than 8After adjusting for non–liver-related risk factors, patients with compensated cirrhosis (defined by CP score <8) can undergo cardiac surgery with cardiopulmonary bypass with no significant increases in postoperative mortality and morbidity. For this group of patients, comorbidities, rather than liver failure, appear to account for the occasional death.
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Small Bowel Pancreatitis27 April 2012
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Melanosis ilei27 April 2012
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Ethnic and Sex Disparities in Colorectal Neoplasia Among Hispanic Patients Undergoing Screening Colonoscopy27 April 2012
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Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype27 April 2012
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Persistent Hyperammonemia Is Associated with Complications and Poor Outcomes in Patients with Acute Liver Failure19 April 2012
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Correction18 April 2012
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Multiple polyposis of the esophagus: Mantle cell lymphoma18 April 2012
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Helicobacter pylori Infection and Nonsteroidal Anti-inflammatory Drug Use: Eradication, Acid-Reducing Therapy, or Both?18 April 2012
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Colonic Angiosarcoma: A Rare Cause of Bleeding16 April 2012
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Discussion16 April 2012
