A 60-year-old North Indian man presented with increased bowel frequency and weight loss during a period of 6 weeks. There was no history of rectal bleeding. The patient had not traveled abroad during the past 3 months. Clinical examination was unremarkable. Laboratory investigations were normal. A colonoscopy showed a large ulcerated mass in the cecum (Figure A). Biopsies showed trophozoites of Entamoeba histolytica (within boxes, Figure B), thus confirming the diagnosis of cecal ameboma. The patient completed a 10-day course of oral metronidazole followed by diloxanide furoate. The patient made an uneventful recovery.
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