Clinical Gastroenterology and Hepatology
Volume 8, Issue 2 , Pages 143-150, February 2010

Algorithms Outperform Metabolite Tests in Predicting Response of Patients With Inflammatory Bowel Disease to Thiopurines

  • Akbar K. Waljee

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Joel C. Joyce

      Affiliations

    • General Clinical Research Center, University of Michigan, Ann Arbor, Michigan
    • ,
  • Sijian Wang

      Affiliations

    • Department of Statistics, University of Wisconsin, Madison, Wisconsin
    • ,
  • Aditi Saxena

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Margaret Hart

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Ji Zhu

      Affiliations

    • Department of Statistics, University of Michigan, Ann Arbor, Michigan
    • ,
  • Peter D.R. Higgins

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Peter D. R. Higgins, MD, PhD, MSc, Division of Gastroenterology, University of Michigan, 6520 MSRB I, Box 0682, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109. fax: (734) 763-2535

published online 15 October 2009.

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     Conflicts of interest The authors disclose the following: The Regents of the University of Michigan, along with authors Peter Higgins, Akbar Waljee, Joel Joyce, Sijian Wang, and Ji Zhu, have applied for a patent on the application of machine learning to patterns in the complete blood count and differential and the comprehensive chemistry panel to the prediction of clinical response to thiopurines. As of December 20, 2009, no patent has yet been granted. The remaining authors disclose no conflicts.

    PII: S1542-3565(09)01011-8

    doi:10.1016/j.cgh.2009.09.031

    Clinical Gastroenterology and Hepatology
    Volume 8, Issue 2 , Pages 143-150, February 2010