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Article Title |
Author(s) |
Type |
Pages |
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The AmpliChip CYP450 Test: Principles, Challenges, and Future Clinical Utility in Digestive Disease
July 2006 (Vol. 4 | No. 7 | Pages 822-830)
Understanding genetically encoded inherited differences in drug metabolism and targets (ie, receptors, transporters) offers the promise of minimizing adverse drug reactions and improving therapies. Am...
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Brian D. Juran,
Laurence J. Egan,
Konstantinos N. Lazaridis
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Full-length article
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pages 822-830
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Genetics of Hepatobiliary Diseases
May 2006 (Vol. 4 | No. 5 | Pages 548-557)
With the recent publication of the first human map of genetic variation (ie, Human Haplotype Map), genomic-based discoveries will likely affect not only the research bench but also the bedside. These ...
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Brian D. Juran,
Konstantinos N. Lazaridis
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Full-length article
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pages 548-557
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A Review of the Genomics of Gastric Cancer
April 2006 (Vol. 4 | No. 4 | Pages 416-425)
Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related death in the world. Over the past 2 decades, many exciting discoveries regarding the genomics of gastric ...
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James P. Hamilton,
Stephen J. Meltzer
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Full-length article
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pages 416-425
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Disaccharide Digestion: Clinical and Molecular Aspects
March 2006 (Vol. 4 | No. 3 | Pages 276-287)
Sugars normally are absorbed in the small intestine. When carbohydrates are malabsorbed, the osmotic load produced by the high amount of low molecular weight sugars and partially digested starches in ...
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Claudia C. Robayo–Torres,
Roberto Quezada–Calvillo,
Buford L. Nichols
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Full-length article
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pages 276-287
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Advances and Perspectives in the Genetics of Inflammatory Bowel Diseases
February 2006 (Vol. 4 | No. 2 | Pages 143-151)
Several clinical and biological phenotypes define complex diseases such as inflammatory bowel disease (IBD). There is a critical role of the caspase recruitment domain protein 15/nucleotide-binding ol...
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Mathias Chamaillard,
Razvan Iacob,
Pierre Desreumaux,
Jean–Frederic Colombel
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Full-length article
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pages 143-151
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Pharmacogenomics in Inflammatory Bowel Disease
January 2006 (Vol. 4 | No. 1 | Pages 21-28)
Inherited variations in the nucleotide sequence of genes influence how individual patients respond to drugs. Most commonly, clinically significant genetic variations consist of single nucleotide polym...
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Laurence J. Egan,
Luc J.J. Derijks,
Daniel W. Hommes
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Full-length article
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pages 21-28
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Gastroduodenal Disease, Helicobacter pylori, and Genetic Polymorphisms
December 2005 (Vol. 3 | No. 12 | Pages 1180-1186)
Over the past 20 years, there has been marked progress in our understanding of the role of genetic and environmental factors in the etiology of gastroduodenal disease. Helicobacter pylori infection no...
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Derek Gillen,
Kenneth E.L. McColl
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Full-length article
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pages 1180-1186
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The Genetics of Irritable Bowel Syndrome
November 2005 (Vol. 3 | No. 11 | Pages 1057-1065)
Because of the heterogeneity in symptoms and diagnostic findings, patients with irritable bowel syndrome (IBS) remain a challenge to treat and to study. This difficulty stems from lack of understandin...
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Yuri A. Saito,
Gloria M. Petersen,
G. Richard Locke,
Nicholas J. Talley
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Full-length article
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pages 1057-1065
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Hemochromatosis: Genetic Testing and Clinical Practice
October 2005 (Vol. 3 | No. 10 | Pages 945-958)
The availability of a facile treatment for hemochromatosis renders early diagnosis of iron overload syndromes mandatory, and in many instances genetic testing allows identification of individuals at r...
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Heinz Zoller,
Timothy M. Cox
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Full-length article
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pages 945-958
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Celiac Disease Genetics: Current Concepts and Practical Applications
September 2005 (Vol. 3 | No. 9 | Pages 843-851)
Celiac disease is a multifactorial disease with complex genetics. Both HLA and non-HLA genes contribute to the genetic component, but recent findings suggest that the importance of non-HLA genes might...
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Ludvig M. Sollid,
Benedicte A. Lie
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Full-length article
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pages 843-851
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Wilson’s Disease
August 2005 (Vol. 3 | No. 8 | Pages 726-733)
Wilson’s disease (WD) is an autosomal recessive inherited disorder leading to impaired intrahepatic trafficking and biliary excretion of copper, resulting in the accumulation of copper in various orga...
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Peter Ferenci
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Full-length article
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pages 726-733
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Inherited Polyposis Syndromes: Molecular Mechanisms, Clinicopathology, and Genetic Testing
July 2005 (Vol. 3 | No. 7 | Pages 633-641)
The inherited polyposis syndromes are a group of conditions in which multiple gastrointestinal polyps occur in the lumen of the gastrointestinal tract, most exhibit an increased risk of colon cancer. ...
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Brett W. Doxey,
Scott K. Kuwada,
Randall W. Burt
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Full-length article
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pages 633-641
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Complex Diseases in Gastroenterology and Hepatology: GERD, Barrett’s, and Esophageal Adenocarcinoma
June 2005 (Vol. 3 | No. 6 | Pages 529-537)
Gastroesophageal reflux disease, Barrett’s esophagus, and esophageal adenocarcinoma are related diseases with environmental and genetic determinants. The genetic changes are relevant in 2 distinct way...
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Rebecca C. Fitzgerald
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Full-length article
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pages 529-537
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Multiple Endocrine Neoplasia Type 2B and Hirschsprung’s Disease
May 2005 (Vol. 3 | No. 5 | Pages 423-431)
Multiple endocrine neoplasia type 2B and Hirschsprung’s disease are genetic disorders characterized by gross and/or microscopic pathology of the enteric nervous system and associated dysmotility. A sp...
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Raj P. Kapur
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Full-length article
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pages 423-431
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Genomics, genetic epidemiology, and genomic medicine
April 2005 (Vol. 3 | No. 4 | Pages 320-328)
Medical science is on the threshold of unparalleled progress as a result of the advent of genomics and related disciplines. Human genomics, the study of structure, function, and interactions of all ge...
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Konstantinos N. Lazaridis,
Gloria M. Petersen
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Full-length article
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pages 320-328
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