Clinical Pathology

A series of invited reviews, based on a clinical case, intended to enhance the use of tissue histopathologyin in the diagnosis of gastrointestinal and liver diseases. The articles illustrate ways to optimize communication, sample acquisition, and processes between the gastroenterologist or hepatologist and the surgical pathologist.

Article Title	Author(s)	Type	Pages
Preinvasive Neoplasia in the Stomach: Diagnosis and Treatment September 2007 (Vol. 5 \| No. 9 \| Pages 1018-1023) Preview Abstract Full Text PDF (2009 KB) This article discusses the proper handling of biopsy samples from mucosal lesions taken from the stomach when there is a suspicion of a malignant process. In addition, the use of endoscopic mucosal re...	Amy Noffsinger, Irving Waxman	Full-length article	pages 1018-1023
Optimizing Diagnosis From the Medical Liver Biopsy August 2007 (Vol. 5 \| No. 8 \| Pages 898-907) Preview Abstract Full Text PDF (4775 KB) The histologic assessment of acute and chronic liver disease is based on an accurate description of the pattern of injury within the tissue specimen. Interpretation of the injury pattern requires revi...	Albert J. Czaja, Herschel A. Carpenter	Full-length article	pages 898-907
Endoscopic Retrograde Cholangiopancreatography Tissue Sampling: When and How? July 2007 (Vol. 5 \| No. 7 \| Pages 783-790) Preview Abstract Full Text PDF (2852 KB) A 69-year-old man presented with obstructive jaundice. Endoscopic retrograde cholangiopancreatography was performed for biliary tree decompression and diagnostic tissue acquisition. Techniques, indica...	Georgios I. Papachristou, Thomas C. Smyrk, Todd H. Baron	Full-length article	pages 783-790
The Malignant Colon Polyp: Diagnosis and Therapeutic Recommendations June 2007 (Vol. 5 \| No. 6 \| Pages 662-667) Preview Abstract Full Text PDF (3971 KB) This article discusses the proper handling of the malignant colon polyp, that is, polypoid lesions that appear endoscopically to represent adenomas and histologically reveal an invasive carcinoma comp...	Marie E. Robert	Full-length article	pages 662-667
Biopsy Considerations in the Diagnosis of Hepatic Masses May 2007 (Vol. 5 \| No. 5 \| Pages 541-544) Preview Abstract Full Text PDF (490 KB) Diagnosis of hepatic masses requires clinical correlation with imaging and pathologic information. In this review we will discuss the differential diagnosis of hepatic masses and present the relevant ...	Robert A. Anders, Ihab R. Kamel	Full-length article	pages 541-544
What to Do When You Suspect Gastrointestinal Lymphoma: A Pathologist’s Perspective April 2007 (Vol. 5 \| No. 4 \| Pages 417-421) Preview Abstract Full Text PDF (700 KB) Although primary gastrointestinal (GI) lymphomas are an infrequent occurrence and represent 1%–4% of the malignant tumors of the GI tract, secondary involvement of the GI tract by lymphoma is not unco...	Sandeep Gurbuxani, John Anastasi	Full-length article	pages 417-421
Diagnosis of Colitis: Making the Initial Diagnosis March 2007 (Vol. 5 \| No. 3 \| Pages 295-301) Preview Abstract Full Text PDF (2145 KB) The evaluation of patients with colitis of recent onset is a relatively common clinical challenge. The main considerations are infectious colitides, idiopathic IBD, ie, ulcerative and Crohn’s colitis,...	Maria T. Abreu, Noam Harpaz	Full-length article	pages 295-301
Gastric Biopsies: Increasing the Yield February 2007 (Vol. 5 \| No. 2 \| Pages 160-165) Preview Abstract Full Text PDF (1854 KB) Gastric biopsies can provide useful information beyond the identification of inflammation or Helicobacter organisms. The key to maximizing the diagnostic yield is providing sufficient context, adequat...	Marian M. Haber	Full-length article	pages 160-165
Diverticular Disease–Associated Segmental Colitis January 2007 (Vol. 5 \| No. 1 \| Pages 27-31) Preview Abstract Full Text PDF (2030 KB) Diverticular disease–associated segmental colitis is a unique variant of chronic colitis limited to segments of the left colon that harbor diverticula. Histologically, this disease mimics chronic idio...	Laura W. Lamps, Whitfield L. Knapple	Full-length article	pages 27-31
Management of High-Grade Dysplasia in Patients With Barrett’s Esophagus December 2006 (Vol. 4 \| No. 12 \| Pages 1434-1439) Preview Abstract Full Text PDF (2474 KB) In the past, the standard management for patients with high-grade dysplasia in Barrett’s esophagus was esophagectomy, in part on the basis of the assumption that the patient was likely to harbor an un...	Elizabeth Montgomery, Marcia Irene Canto	Full-length article	pages 1434-1439
Surveillance of Dysplasia in Inflammatory Bowel Disease: The Gastroenterologist-Pathologist Partnership November 2006 (Vol. 4 \| No. 11 \| Pages 1309-1313) Preview Abstract Full Text PDF (1005 KB) Cancer prevention in inflammatory bowel disease depends on the detection of precancerous dysplasia during scheduled screening and surveillance colonoscopy, but the detection and diagnosis of dysplasia...	David T. Rubin, Jerrold R. Turner	Full-length article	pages 1309-1313
Malabsorption Work-up: Utility of Small Bowel Biopsy October 2006 (Vol. 4 \| No. 10 \| Pages 1193-1198) Preview Abstract Full Text PDF (5752 KB) A wide variety of small intestinal mucosal diseases lead to malabsorption. Although stool studies, especially stool for excess fat, and functional tests for deficiency states are important clues to ma...	Brian A. Babbin, Kelly Crawford, Shanthi V. Sitaraman	Full-length article	pages 1193-1198